PhysioEx™ 9.1 Content Information
PhysioEx™ 9.1: Laboratory Simulations in Physiology is easy-to-use laboratory simulation software that consists of 12 exercises containing 63 physiology lab activities that can be used to supplement or substitute wet labs. PhysioEx allows students to repeat labs as often as they like, perform experiments without harming live animals, and conduct experiments that are difficult to perform in a wet lab environment because of time, cost, or safety concerns.

PhysioEx 9.1 is an update of PhysioEx 9.0 and features input data variability that allows students to change variables and test out various hypotheses for the experiments. PhysioEx 9.1 retains the popular new improvements introduced in 9.0, including onscreen step-by-step instructions and "Stop & Think" and "Predict" questions that help students think about the connection between the experiments and the physiological concepts they demonstrate.

  • 63 lab activities cover topics such as cell transport, skeletal muscle contraction, irritability and conductivity of neurons, hormones and metabolism, cardiovascular dynamics, respiratory processes, digestion, glomerular filtration, acid/base balance, and more.
  • Students have the flexibility to experiment with multiple variables and observe how outcomes are affected. Experimental data can be recorded on screen and printed out as hard copies.
  • An extensive histology tutorial includes more than 250 histology images, viewable in various magnifications and searchable by tissue type, organ system, or alphabetically.
  • Lab worksheets fully support students by walking them through each lab step-by-step.
  • Online worksheets in multiple-choice format are available for each lab, providing the student instant feedback on how they understand the lab results. The worksheets may also be emailed to instructors as assignments.
  • Short video clips of certain lab equipment in use help students make connections between on-screen renderings and the real equipment they represent. The seven videos demonstrate the following experiments: Skeletal Muscle, Blood Typing, Cardiovascular Physiology, Water-Filled Spirometry, Nerve Impulses, BMR Measurement, and Cell Transport.
  • Review Sheets follow their respective exercise and ask the questions one would pose after the student has done the lab exercises.
  • Illustrations relate the onscreen lab equipment to the corresponding human body structures in certain labs to help students understand the relationship.
  • Online format with easy step-by-step instructions so everything the student needs to do is located in one convenient place. After the student performs a step, instructions for the next step appear. Students gather data, analyze results, and check their understanding all on screen.
  • Stop & Think Questions and Predict Questions help students think about the connection between the activities and the physiological concepts they demonstrate. As the students go through the steps of an experiment, they're asked Stop & Think questions about the activity and the relevant physiological principles to check their understanding before moving on. Students are also asked to make predictions about the results for an experiment to apply what they have learned before seeing the results.
  • Greater data variability in the results reflects more realistic results students would encounter in real wet-lab experiments.
  • Lots of opportunities to assess understanding via pre-lab quizzes, post-lab quizzes, and short-answer review sheets are offered to students for every activity.
  • Students can save their Lab Report as a PDF, add their name, and then print and/or email the file to their instructor.
  • A Test Bank of assignable pre-lab and post-lab quizzes for use with TestGen® or their course management system is provided for instructors.
Table of Contents
1. Cell Transport Mechanisms and Permeability
2. Skeletal Muscle Physiology
3. Neurophysiology of Nerve Impulses
4. Endocrine System Physiology
5. Cardiovascular Dynamics
6. Cardiovascular Physiology
7. Respiratory System Mechanics
8. Chemical and Physical Processes of Digestion
9. Renal System Physiology
10. Acid-Base Balance
11. Blood Analysis
12. Serological Testing

Major changes to PhysioEx content since version 8.0:

Exercise 1: Cell Transport Mechanisms and Permeability

Activity 5: Simulating Active Transport, a simplified cell is modeled to help students correlate active transport to a cellular process.

Exercise 2: Skeletal Muscle Physiology

Activity 1 (Practice Generating a Trace) was removed, as this is a component of all the other activities in this exercise.

Activities 4 and 5 (Investigating Treppe and Investigating Wave Summation) were consolidated into a single activity, Activity 3: The Effect of Stimulus Frequency on Skeletal Muscle Contraction.

Activity 5: Fatigue in Isolated Skeletal Muscle (Activity 7 in PhysioEx™ 8) was revised so that the student can observe the effect of recovery time on the development of fatigue in skeletal muscle.

Activity 7: Isotonic Contractions and the Load-Velocity Relationship (Activity 9 in PhysioEx™ 8) was revised to show distance on the Y-axis and isotonic concentric twitches on the oscilloscope.

Exercise 3: Neurophysiology of Nerve Impulses

Exercise 3 was dramatically revised and expanded. The following activities are now available in Exercise 3:

Activity 1: The Resting Membrane Potential
Activity 2: Receptor Potential
Activity 3: The Action Potential: Threshold
Activity 4: The Action Potential: Importance of Voltage-Gated Na+ channels
Activity 5: The Action Potential: Measuring Its Absolute and Relative Refractory Periods
Activity 6: The Action Potential: Coding for Stimulus Intensity
Activity 7: The Action Potential: Conduction Velocity
Activity 8: Chemical Synaptic Transmission and Neurotransmitter Release
Activity 9: The Action Potential: Putting It All Together

Exercise 4: Endocrine System Physiology

Activities 1-4 (Determining Baseline Metabolic Rates, Determining the Effect of Thyroxine on Metabolic Rate, Determining the Effect of TSH on Metabolic Rate, and Determining the Effect of Propylthiouracil on Metabolic Rate) were consolidated into a single activity, Activity 1: Metabolism and Thyroid Hormone.

Palpation for goiter development in the rat's throat has been included in this activity to expand the range of student inquiry about negative feedback and the control of thyroid hormone secretion.

Activities 6 (Obtaining a Glucose Standard Curve) and 7 (Measuring Fasting Plasma Glucose) were consolidated into a single activity, Activity 2: Plasma Glucose, Insulin, and Diabetes Mellitus.

Exercise 5: Cardiovascular Dynamics

In activities 1-5, questions have been included to remind students how changes to blood flow occur in the body and correlate the components used in the simulation to structures in the body.

Activity 6: Studying the Effect of Stroke Volume on Pump Activity has been redesigned to correlate the Frank-Starling law in the heart to the activity.

Activities 7 and 8 were consolidated into an expanded activity, Activity 7: Compensation in Pathological Cardiovascular Conditions. Like Activity 6, this revised activity correlates the Frank-Starling law in the heart to the activity.

Exercise 6: Cardiovascular Physiology

Activity 1 (Recording Baseline Frog Heart Activity) was removed, as this is a component of all the other activities in this exercise.

Activities 5-8 (Assessing the Effect of Pilocarpine, Assessing the Effect of Atropine, Assessing the Effect of Epinephrine, and Assessing the Effect of Digitialis) were consolidated into a single activity, Activity 4: Examining the Effects of Chemical Modifiers on Heart Rate.

Activities 4 and 5 have been redesigned to include correlations with cholinergic and adrenergic modifiers and chronotropic and inotropic modifiers.

Exercise 7: Respiratory System Mechanics

Activities 1 and 2 (Measuring Respiratory Volumes and Examining the Effect of Changing Airway Resistance on Respiratory Volumes) were consolidated into a single activity, Activity 1: Measuring Respiratory Volumes and Calculating Capacities.

Activities 3 and 4 (Examining the Effect of Surfactant and Investingating Intrapleural Pressuer were consolidated into a single activity, Activity 3: Effect of Surfactant and Intrapleural Pressure on Respiration.

Activity 5 (Exploring Various Breathing Patterns) was removed.

Exercise 8: Chemical and Physical Processes of Digestion

The effects of temperature on enzyme activity have been combined in Activity 1: Assessing Starch Digestion by Salivary Amylase, rather than having them tested separately in Activities 1 and 2, for consistency.

Exercise 9: Renal Physiology

Onscreen labels that identify components of the nephron now appear as fluid moves through the simulated nephron during the first run of every activity.

In activities 4-6, fixed data monitors have been placed in the simulated nephron to make it easier for the student to observe concentration changes in the filtrate.

Exercise 10: Acid-Base Balance

Activities 1 and 2 (Hyperventilation-Run 1 and Hyperventilation-Run 2) were consolidated into a single activity, Activity 1: Hyperventilation.

Activities 4-6 (Renal Response to Normal Acid-Base Balance, Renal Response to Respiratory Alkalosis, and Renal Response to Respiratory Acidosis) were consolidated into a single activity, Activity 3: Renal Responses to Respiratory Acidosis and Respiratory Alkalosis.

Activities 7-9 (Respiratory Response to Normal Metabolism, Respiratory Response to Increased Metabolism, and Respiratory Response to Decreased Metabolism) were consolidated into a single activity, Activity 4: Respiratory Responses to Metabolic Acidosis and Metabolic Alkalosis.